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Index > Protein center > Uba1(Gene name) > Mouse
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  • Uba1 (Gene name),
  • Ubiquitin-like modifier-activating enzyme 1 (Protein name ),  UBA1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Uba1(Sbx;Ube1;Ube1ax;Ube1x);
    Protein name:
    Ubiquitin-like modifier-activating enzyme 1;
    Alternative:
    Ubiquitin-activating enzyme E1 X;Ubiquitin-activating enzyme E1;Ubiquitin-like modifier-activating enzyme 1 X;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Monomer. Interacts with GAN (via BTB domain).
    Function:
    Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    1058
    Sequence:
    50:
    MSSSPLSKKR | RVSGPDPKPG | SNCSPAQSAL | SEVSSVPTNG | MAKNGSEADI | 
    100:
    DESLYSRQLY | VLGHEAMKML | QTSSVLVSGL | RGLGVEIAKN | IILGGVKAVT | 
    150:
    LHDQGTTQWA | DLSSQFYLRE | EDIGKNRAEV | SQPRLAELNS | YVPVTAYTGP | 
    200:
    LVEDFLSSFQ | VVVLTNSPLE | AQLRVGEFCH | SRGIKLVVAD | TRGLFGQLFC | 
    250:
    DFGEEMVLTD | SNGEQPLSAM | VSMVTKDNPG | VVTCLDEARH | GFETGDFVSF | 
    300:
    SEVQGMIQLN | GCQPMEIKVL | GPYTFSICDT | SNFSDYIRGG | IVSQVKVPKK | 
    350:
    ISFKSLPASL | VEPDFVMTDF | AKYSRPAQLH | IGFQALHQFC | ALHNQPPRPR | 
    400:
    NEEDATELVG | LAQAVNARSP | PSVKQNSLDE | DLIRKLAYVA | AGDLAPINAF | 
    450:
    IGGLAAQEVM | KACSGKFMPI | MQWLYFDALE | CLPEDKEALT | EEKCLPRQNR | 
    500:
    YDGQVAVFGS | DFQEKLSKQK | YFLVGAGAIG | CELLKNFAMI | GLGCGEGGEV | 
    550:
    VVTDMDTIEK | SNLNRQFLFR | PWDVTKLKSD | TAAAAVRQMN | PYIQVTSHQN | 
    600:
    RVGPDTERIY | DDDFFQNLDG | VANALDNIDA | RMYMDRRCVY | YRKPLLESGT | 
    650:
    LGTKGNVQVV | IPFLTESYSS | SQDPPEKSIP | ICTLKNFPNA | IEHTLQWARD | 
    700:
    EFEGLFKQPA | ENVNQYLTDS | KFVERTLRLA | GTQPLEVLEA | VQRSLVLQRP | 
    750:
    QTWGDCVTWA | CHHWHTQYCN | NIRQLLHNFP | PDQLTSSGAP | FWSGPKRCPH | 
    800:
    PLTFDVNNTL | HLDYVMAAAN | LFAQTYGLTG | SQDRAAVASL | LQSVQVPEFT | 
    850:
    PKSGVKIHVS | DQELQSANAS | VDDSRLEELK | ATLPSPDKLP | GFKMYPIDFE | 
    900:
    KDDDSNFHMD | FIVAASNLRA | ENYDISPADR | HKSKLIAGKI | IPAIATTTAA | 
    950:
    VVGLVCLELY | KVVQGHQQLD | SYKNGFLNLA | LPFFGFSEPL | AAPRHQYYNQ | 
    1000:
    EWTLWDRFEV | QGLQPNGEEM | TLKQFLDYFK | TEHKLEITML | SQGVSMLYSF | 
    1050:
    FMPAAKLKER | LDQPMTEIVS | RVSKRKLGRH | VRALVLELCC | NDESGEDVEV | 
    1058:
    PYVRYTIR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    SMR:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Ubiquitin-like modifier-activating enzyme 1
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    ELISA Kit for Mouse Ubiquitin-like modifier-activating enzyme 1
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    ELISA Kit for Mouse Ubiquitin-like modifier-activating enzyme 1
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    ELISA Kit for Mouse Ubiquitin-like modifier-activating enzyme 1
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    E12404b
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    ELISA Kit for Mouse Ubiquitin-like modifier-activating enzyme 1
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    E12404m
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    96T
    CLIA Kit for Mouse Ubiquitin-like modifier-activating enzyme 1
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    U12404h
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    96T
    CLIA Kit for Mouse Ubiquitin-like modifier-activating enzyme 1
    Cat.:
    U12404b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Ubiquitin-like modifier-activating enzyme 1
    Cat.:
    U12404m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Ubiquitin-like modifier-activating enzyme 1
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Ubiquitin-like modifier-activating enzyme 1
    Cat.:
    U12404r
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse Ubiquitin-like modifier-activating enzyme 1
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    P12404Rb-m
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    Polyclonal Antibody for Mouse Ubiquitin-like modifier-activating enzyme 1
    Polyclonal Antibody for Mouse Ubiquitin-like modifier-activating enzyme 1
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    P12404Rb-h
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    Packing:
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    Polyclonal Antibody for Mouse Ubiquitin-like modifier-activating enzyme 1
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    P12404Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Ubiquitin-like modifier-activating enzyme 1
    Monoclonal Antibody for Mouse Ubiquitin-like modifier-activating enzyme 1
    Monoclonal Antibody for Mouse Ubiquitin-like modifier-activating enzyme 1
    Monoclonal Antibody for Mouse Ubiquitin-like modifier-activating enzyme 1
    Monoclonal Antibody for Mouse Ubiquitin-like modifier-activating enzyme 1
    Monoclonal Antibody for Mouse Ubiquitin-like modifier-activating enzyme 1
    Protein for Mouse Ubiquitin-like modifier-activating enzyme 1
    Protein for Mouse Ubiquitin-like modifier-activating enzyme 1
    Protein for Mouse Ubiquitin-like modifier-activating enzyme 1
    Protein for Mouse Ubiquitin-like modifier-activating enzyme 1
    Protein for Mouse Ubiquitin-like modifier-activating enzyme 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and sequence of a functionally active cDNA encoding the mouse ubiquitin-activating enzyme E1."
      Imai N. , Kaneda S. , Nagai Y. , Seno T. , Ayusawa D. , Hanaoka F. , Yamao F.
      Gene118:279-282(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: NOD.
      tissue: Ovary.
      tissue: Thymus.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    5. 5.
      Lubec G. , Klug S. , Kang S.U.
      Submitted (2007-04) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 69-81; 90-97; 175-182; 227-239; 351-368; 375-384; 386-411; 451-465; 471-485; 538-551; 559-581; 593-604; 636-671; 679-693; 785-802; 844-851; 870-880; 890-923; 945-980 AND 1011-1021;IDENTIFICATION BY MASS SPECTROMETRY
      strain: C57BL/6.
      tissue: Brain.
      tissue: Hippocampus.
    6. 6.
      "Homology of a candidate spermatogenic gene from the mouse Y chromosome to the ubiquitin-activating enzyme E1."
      Mitchell M.J. , Woods D.R. , Tucker P.K. , Opp J.S. , Bishop C.E.
      Nature354:483-487(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 615-1058
      strain: 129/Sv.
    7. 7.
      "Estimating the intensity of male-driven evolution in rodents by using X-linked and Y-linked Ube 1 genes and pseudogenes."
      Chang B.H.-J. , Li W.H.
      J. Mol. Evol.40:70-77(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 655-763
      strain: BALB/c AnCr.
      tissue: Liver.
    8. 8.
      "Isolation of genomic DNA fragments corresponding to genes modulated in vivo by a transcription factor."
      Caubin J. , Iglesias T. , Bernal J. , Munoz A. , Marquez G. , Barbero J.L. , Zaballos A.
      Nucleic Acids Res.22:4132-4138(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REGULATION OF EXPRESSION BY THE THYROID HORMONE RECEPTOR
    9. 9.
      "Transcriptional analysis of the candidate spermatogenesis gene Ube1y and of the closely related Ube1x shows that they are coexpressed in spermatogonia and spermatids but are repressed in pachytene spermatocytes."
      Odorisio T. , Mahadevaiah S.K. , McCarrey J.R. , Burgoyne P.S.
      Dev. Biol.180:336-343(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    10. 10.
      "Proteomic identification of proteins conjugated to ISG15 in mouse and human cells."
      Giannakopoulos N.V. , Luo J.K. , Papov V. , Zou W. , Lenschow D.J. , Jacobs B.S. , Borden E.C. , Li J. , Virgin H.W. , Zhang D.E.
      Biochem. Biophys. Res. Commun.336:496-506(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ISGYLATION
    11. 11.
      "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
      J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-55;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Mast cell.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-816 AND SER-820;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    13. 13.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-671;SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-528;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
    14. 14.
      "Crystal structure of a fragment of mouse ubiquitin-activating enzyme."
      Szczepanowski R.H. , Filipek R. , Bochtler M.
      J. Biol. Chem.280:22006-22011(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 626-891
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